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使用抗溶剂沉方法制备,表征,稳定性和功能性质的andrographolide加载的kafirin/carboxymethyl纤维素复合颗粒使用抗溶剂沉方法

Mengyu Qian¹, Hao Shi², Fei Wang¹

¹Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.

International journal of biological macromolecules

|November 28, 2024

概括

咖啡因 (Kaf) 和甲纤维素 (CMC) 复合纳米颗粒有效封装andrographolide (AG),改善其口服生物利用性和稳定性. 这些新型纳米颗粒显示出治疗应用和营养药配方的前景.

科学领域:

食品科学食品科学食品科学
材料科学材料科学材料科学
生物技术是生物技术.

背景情况:

疏水性营养药需要有效的输送系统来增强口服生物可用性.
封装保护生物活性成分,并改善营养药的稳定性.
咖啡因 (Kaf) 和碳素甲基纤维素 (CMC) 是生物相容的聚合物,具有纳米粒子配方的潜力.

研究的目的:

准备和表征kafirin (Kaf) /carboxymethyl纤维素 (CMC) 复合纳米颗粒用于封装andrographolide (AG).
评估CMC对Kaf纳米颗粒性能和性能的影响.
评估AG载荷复合纳米粒子的生物安全性和治疗潜力.

主要方法:

抗溶剂沉方法用于纳米粒子制备.
咖啡因 (Kaf) 和碳素甲基纤维素 (CMC) 在 4:1 的质量比率中使用,以获得最佳的结果.
纳米粒子的表征包括尺寸分析,水分散性评估和相互作用研究.

主要成果:

最佳的Kaf/CMC比率产生了平均直径为146.4纳米的纳米粒子.
CMC显著提高了纳米粒子在水中的可分散性.
与Kaf纳米颗粒相比,Kaf/CMC纳米颗粒显示出更好的封装效率,胃肠道释放和稳定性.
复合纳米粒子表现出优越的生物安全性和抗癌效果.

结论:

咖啡因 (Kaf) /碳素甲基纤维素 (CMC) 复合纳米颗粒为疏水性营养品和药物提供了一个有前途的输送系统.
这些纳米颗粒的增强性质有助于药物输送和营养药配方的进步.
该研究强调了这些复合纳米粒子在治疗应用中的潜力.

关键词:

安德罗格拉福利德 (Andrographolide) 是一种色蛋白质.疏水性营养载体疏水性营养载体咖啡林/碳甲基纤维素复合纳米颗粒.

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