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A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

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印刷的聚乳酸/阿克曼酸复合脚手架用于骨组织工程;开发和表面修改.

Arab Eshagh Abadi Mostafa¹, Rahmatollah Emadi¹, Danial Shirali¹

¹Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.

International journal of biological macromolecules

|November 28, 2024

概括

这项研究优化了用Akermanite用于骨组织工程的多乳酸支架. 20%重量Akermanite复合物显示增强了细胞粘附和机械强度,使其成为骨再生的理想选择.

关键词:

通过3D打印打印3D打印.亚克曼尼特是一种亚克曼尼特.性表面修饰性表面修饰骨组织工程骨组织工程纳米复合材料的脚手架.聚乳酸是一种多乳酸.

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科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
材料科学材料科学材料科学

背景情况:

骨组织容易受到衰老,事故和疾病造成的损伤.
有效的骨组织工程需要先进的生物材料用于脚手架的发展.

研究的目的:

确定用于骨组织工程的多乳酸 (PLA) 支架中最佳的阿克尔曼酸 (AK) 添加物.
为了研究表面修改对PLA/AK复合脚手架性能的影响.

主要方法:

亚克曼 (AK) 通过sol-gel方法合成.
聚乳酸 (PLA) 复合脚手架具有不同的AK含量 (0-30重量%) 使用化沉积建模 (FDM) 制造.
使用X射线衍射,细胞活力,细胞粘附和机械测试进行表征. 使用氧化进行表面修饰.

主要成果:

X射线衍射证实了高纯度的阿克曼石阶段.
复合材料支架显示无毒性,并改善了细胞粘附性,随着AK含量的增加.
压力强度随着AK含量增加而增加,建议20重%的AK是最佳的.

结论:

20%重量的AK复合脚手架是骨组织工程应用的最佳选择.
表面修改的PLA/AK支架显示出在骨再生中具有先进医疗应用的潜力.
这项研究有助于组织工程的进步,以改善骨治疗.