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Updated: Jun 6, 2025

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
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对Onivyde®的逆向工程 - - 虹膜素脂质体注射

Jingyao Gan1, Vivian Juang1, Kaikai Wang1

  • 1Department of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

International journal of pharmaceutics
|November 28, 2024
PubMed
概括

这项研究开发了分析方法来表征Onivyde®,一种脂质体内注射的虹素素. 这些方法评估了这种复杂的胰腺癌治疗的关键质量属性.

关键词:
分析方法 分析方法标志性描述 标志性描述药物释放药物释放的时间脂质细胞体中的脂肪体.在Onivyde®上使用.量化 量化 量化 量化

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Drug Biotransformation: Overview01:16

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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