跨诊断和诊断特定的形态相似性与注意力缺陷/多动障碍和自闭症谱系障碍的转录特征相关
Fanyu Zhang1, Lin Liu1, Jinzhong Peng1
1University of Electronic Science and Technology of China, Chengdu, China.
Journal of the American Academy of Child and Adolescent Psychiatry
|November 28, 2024
概括
注意缺陷/多动障碍 (ADHD) 和自闭症谱系障碍 (ASD) 共享大脑结构变化,特别是在右侧中回,表明共同的潜在机制. 基因分析揭示了神经刺激和抑制的共同途径.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 注意缺陷/多动症障碍 (ADHD) 和自闭症谱系障碍 (ASD) 是具有高并发症的遗传性发育障碍.
- 了解共同和独特的病理生理机制对于ADHD和ASD都至关重要.
研究的目的:
- 研究ADHD和ASD的跨诊断和诊断特异性结构性大脑变化.
- 探索ADHD和ASD背后的相关细胞和遗传机制.
主要方法:
- 利用了来自247名受试者的结构磁共振成像 (MRI) 数据 (91名多动症,49名自闭症,107名对照).
- 进行了形态相似性网络 (MSN) 分析和基因转录特征分析.
- 对ADHD/ASD风险基因和MSN相关基因进行了丰富分析.
主要成果:
- ADHD在认知功能领域显示出诊断特定的MSN变化;ASD在语言和空间位置领域显示出变化.
- 在ADHD和ASD中观察到右侧中间状环的跨诊断性增加.
- 基因分析揭示了ADHD和ASD风险基因在突触传播和发育途径中的丰富,包括激发性和抑制性神经元中的基因.
结论:
- 右中旋中的跨诊断形态变化可能表明ADHD和ASD有共同的运动障碍.
- 基因转录档案表明,在这两种条件下,刺激性和抑制性神经通路的潜在不平衡.
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