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金属氨-1/2无菌小鼠的口味偏好和有条件的口味厌恶

Nanae Yasuura¹, Tadashi Inui², Tomohiko Yoshizawa²

¹Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan; Orthodontics, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan.

Physiology & behavior

|November 28, 2024

概括

在小鼠中,metallothionein-1/2基因淘汰增加了甜味偏好,但没有影响受条件的味道厌恶. 这表明metallothionein在其中.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
生理学生理学生理学

背景情况:

金属氨酸 (MTs) 是参与金属恒温和细胞保护的蛋白质.
在味觉和厌恶学习中,MT-1/2在味觉和厌恶学习中的作用尚不清楚.

研究的目的:

为了研究MT-1/2基因淘汰对小鼠口味偏好和条件口味厌恶 (CTA) 的影响.
探索MT-1/2,水平和味觉行为之间的关系.

主要方法:

野生型 (WT) 和MT-1/2无 (KO) 类小鼠行为的比较.
对糖,盐和苦溶液的口味偏好评估.
使用糖和化 (LiCl) 调节的CTA获取的评估.
测量正常和低饮食的小鼠的血度.

主要成果:

与WT小鼠相比,MT-1/2 KO小鼠对糖溶液的偏好明显更高.
在WT和KO小鼠之间没有观察到盐或苦溶液偏好的显著差异.
无论是WT和KO小鼠都开发了标记的CTA到糖.
血度在两种基因型中都保持在生理范围内,即使在低饮食中.

结论:

MT-1/2 在调节甜味偏好方面发挥作用.
甜味诱导的CTA获取背后的大脑机制在MT-1/2 KO小鼠中被保留.
在测试的饮食条件下,MT似乎没有积极参与调节血度.

关键词:

有条件的味道厌恶.MT-1/2 没有数据的小鼠在金属氨酸中.等离子体中的.品味偏好品味偏好

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