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相关概念视频

X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

3.8K
X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
3.8K
X-ray Crystallography02:18

X-ray Crystallography

23.8K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
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相关实验视频

Updated: Jun 6, 2025

Fixed Target Serial Data Collection at Diamond Light Source
06:19

Fixed Target Serial Data Collection at Diamond Light Source

Published on: February 26, 2021

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使用DIALS处理串行同步晶体学衍射数据.

James Beilsten-Edmands1, James M Parkhurst2, Graeme Winter1

  • 1Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom.

Methods in enzymology
|November 28, 2024
PubMed
概括
此摘要是机器生成的。

新的软件增强改进了序列结晶学数据处理. 该DIALS套件和xia2.ssx管道提供更好的整合使用3D高斯形状模型的部分静止镜像衍射数据.

关键词:
拨号器可以拨号.数据整合数据集成数据处理数据处理.数据减少数据的减少.序列晶体学 序列晶体学一个小2.ssxx.

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Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography
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Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

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相关实验视频

Last Updated: Jun 6, 2025

Fixed Target Serial Data Collection at Diamond Light Source
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Fixed Target Serial Data Collection at Diamond Light Source

Published on: February 26, 2021

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Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography
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Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

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科学领域:

  • 结构生物学 结构生物学
  • 晶体学 晶体学是指结晶学.
  • 软件开发 软件开发

背景情况:

  • 连续静拍结晶学 (SSX) 对于研究动态生物过程至关重要.
  • 准确处理部分衍射数据对于成功的SSX实验至关重要.
  • 现有的软件在处理异型点形状和部分性方面可能存在局限性.

研究的目的:

  • 描述用于SSX数据处理的DIALS软件包的新增内容.
  • 引入 xia2.ssx 管道用于处理和合并 SSX 数据.
  • 改进部分静止镜像衍射数据的整合和分析.

主要方法:

  • 开发一个3D高斯形状模型的3D高斯形状模型的异型点形状.
  • 使用最大概率方法优化个人资料模型.
  • 实施Xia2.ssx管道,集成SSX数据的DIALS程序.

主要成果:

  • 新的模型可以同时改进配置模型和Ewald球体偏移.
  • 与同位素模型相比,改进的部分性估计导致了更好的模型统计.
  • 展示合并SSX数据的工作流程,包括时间/剂量解析序列.

结论:

  • 增强的DIALS套件和xia2.ssx管道显著改善了SSX数据处理.
  • 3D高斯形状模型提高了整合部分衍射数据的准确性.
  • 开发的工具促进了先进的SSX数据分析,包括时间解决的研究.