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肝细胞癌的全身疗法

Emily Kinsey¹, Michael A Morse²

¹Department of Medicine, Division of Hematology, Oncology & Palliative Care, VCU Health, Richmond, VA, USA.

Clinics in liver disease

|November 28, 2024

概括

肝细胞癌的全身治疗现在包括免疫检查点抑制剂. 未来的治疗重点是辅助设置和患有晚期肝功能障碍的患者.

科学领域:

肝胆道癌症肝胆道癌症
医学瘤学医学瘤学
免疫治疗是一种免疫疗法.

背景情况:

肝细胞癌 (HCC) 系统治疗已取得显著进展.
像索拉芬尼布这样的初步治疗方法已经被新的选择所超越.
目前的标准包括免疫检查点抑制剂 (ICI).

研究的目的:

审查肝细胞癌全身治疗的演变情况.
突出当前的治疗标准和新兴的治疗策略.
讨论HCC治疗研究的未来方向.

主要方法:

对肝细胞癌的全身疗法的文献综述.
对当前临床试验数据和治疗指南的分析.
确定正在进行和未来的研究领域.

主要成果:

一线治疗已经转向ICI组合 (阿特佐利祖马布/贝瓦西祖马布,杜尔瓦卢马布/特雷梅利穆马布).
即将推出的疗法包括camrelizumab/rivoceranib和nivolumab/ipilimumab. 这两种疗法将在未来推出.
第二线选择仍然是多酶抑制剂或拉穆西鲁马布.

结论:

免疫检查点封锁是第一线HCC治疗的新标准.
研究正在扩展到辅助设置和患有Child-Pugh B肝功能的患者.
新的检查点分子和组合策略正在调查中.

关键词:

在Atezolizumab中使用.贝瓦西祖马布 (bevacizumab) 是一种药物.卡博桑提尼布 (Cabozantinib) 是一种药物.在 Durvalumab 中使用.我不喜欢他们,我不喜欢他们.伦瓦提尼布 (Lenvatinib) 是一种药物.尼沃卢马布的使用情况这就是Tremelelimumab.

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