辛提利马布加HPV疫苗治疗复发性或转移性宫癌
Buhai Wang1,2, Yichen Liang3,2, Yuechao Wu4
1Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China Gujuan88@hotmail.com wbhself@sina.com.
Journal for immunotherapy of cancer
|November 28, 2024
概括
这项研究探讨了sintilimab与人类乳头瘤病毒 (HPV) 疫苗结合用于复发或转移性子宫癌 (r / m CC) 的研究. 该组合在治疗选择有限的患者中显示出有希望的客观反应率 (ORR).
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 再发性或转移性子宫癌 (r/m CC) 的二线治疗选择有限.
- 标准疗法经常失败或导致r/mCC患者的快速进展.
研究的目的:
- 调查sintilimab加上预防性人类乳头瘤病毒 (HPV) 四价疫苗作为r/m CC的二线治疗方法.
- 评估这种组合治疗在对第一线治疗不反应或不耐受患者的疗效和安全性.
主要方法:
- 2期临床试验,涉及患有r/m CC.的患者.
- 治疗方案:每3周服用辛蒂利马布,再加上3剂HPV四价疫苗.
- 主要终点:客观响应率 (ORR);使用西蒙两阶段最佳设计.
主要成果:
- 观察到的客观反应率 (ORR) 为53.8% (95%CI为25.1%至80.8%).
- 疾病控制率为76.9% (95% CI 46.2%至95.0%),中位数无进展生存时间为7.16个月.
- 没有报告3级或以上的不良事件;甲状腺功能低下是最常见的AE (15.6%).
结论:
- 辛提利马布加上预防性HPV疫苗为r/mCC提供了一个潜在的有希望的治疗策略.
- 这种组合为那些对标准疗法不反应或不耐受的r/mCC患者提供了一个新的选择.
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