随着年龄的增长,功能下降的速度:一个系统性审查
Michelle Guppy1,2, Elizabeth Taruna Thomas3, Paul Glasziou4
1Institute for Evidence-Based Healthcare, Bond University Faculty of Health Sciences and Medicine, Gold Coast, Queensland, Australia mguppy2@une.edu.au.
BMJ open
|November 28, 2024
概括
这一系统性审查发现,健康成年人的功能每年下降,正常速率在 -0.37 和 -1.07 mL/min/1.73 m2/年之间,对于没有高血压的人来说. 这些发现有助于临床医生预测功能轨迹,并确定慢性病护理需求.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 功能自然会随着年龄的增长而下降.
- 了解健康个体的这种衰退对于识别病的早期症状至关重要.
- 以前的研究还没有系统地综合了健康人群中功能下降率的数据.
研究的目的:
- 为了确定功能分布,用膜过率 (GFR) 测量,在健康个体中.
- 为了评估男性和女性健康受试者随着年龄的增长,功能下降的速度.
- 在没有先前存在的疾病的情况下,建立正常功能下降的基准.
主要方法:
- 一个系统的审查和相关文献的结构化综合.
- 搜索了主要的数据库 (PubMed,Embase等) 和临床试验注册到2023年10月.
- 包括观察性队列研究和对照试验的非治疗臂,评估与年龄相关的功能下降.
主要成果:
- 分析了12项涉及129,359名健康参与者的研究 (1958-2021年).
- 功能每年下降率在 -0.24 到 -3.60 mL/min/1.73 m2/year (或 -0.37 到 -1.07 在没有高血压的人群中) 之间.
- 关于衰退率是否随着年龄增长而加快或性别之间存在差异,观察到相矛盾的结果;无法确定特定种族的比例.
结论:
- 这是首次对健康个体纵向功能下降的系统综述.
- 在没有高血压的健康成年人中,正常下降率估计在 -0.37 和 -1.07 mL/min/1.73 m2/年之间.
- 这些发现可以帮助临床医生预测患者的病轨迹,并确定慢性病护理的必要性.
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