静脉注射乙氨基诱导的低血压的危险因素在重复服用乙氨基的患者中
Sung-Ryeol Kim1, Nak-Hoon Son2, Kyung Hee Park3,4
1Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
Yonsei medical journal
|November 28, 2024
概括
输入式乙氨基的低血压是不可预测的. β阻塞剂,肠胃感染和败血栓休克会增加风险,但患者的健康状况是关键.
科学领域:
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
- 临床风险管理临床风险管理
背景情况:
- 静脉注射 (IV) 乙氨基广泛用于疼痛和发烧管理.
- 在静脉注射乙氨基后的低血压是一个重大的临床问题.
- 预测IV乙氨基诱导的低血压仍然具有挑战性.
研究的目的:
- 为了确定与低血压相关的因素,在患者接受重复的IV乙氨基.
- 为了改善IV乙氨基诱导的低血压的预测.
主要方法:
- 在重症监护病房内接受IV乙氨基的患者的观察队列研究.
- 血压变化在IV乙氨基给药后2小时内进行分析.
- 低血压的定义:静缩血压<90 mm Hg,或降低30 mm Hg,或平均动脉压降低15%.
主要成果:
- 26.9%的IV乙氨基 (416/1547) 导致低血压.
- 使用β-阻断剂 (OR=1.50),胃肠道感染 (OR=1.42) 和败血症休克 (OR=1.68) 是显著的危险因素.
- 在服用β阻塞剂的患者中,心力衰竭 (OR=1.91) 和尿路感染 (OR=2.16) 也是显著的危险因素.
结论:
- 严重的感染,心力衰竭和β抑制剂的使用与IV乙氨基诱导的低血压有关.
- 乙氨基诱导的低血压是不一致的,并且取决于患者.
- 进一步的研究可能有助于预测和管理这种不良事件.
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