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Updated: Jun 6, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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GPNMB是FGFR1的新型结合伙伴,通过TNBC中的AKT酸化影响瘤发生潜力

Manar A Elhinnawi1,2,3, Yukari Okita1,4, Katsunobu Shigematsu1

  • 1Department of Experimental Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.

Cancer science
|November 28, 2024
PubMed
概括

糖蛋白非转移性黑色素瘤蛋白B (GPNMB) 和纤维细胞生长因子受体1 (FGFR1) 是侵袭性三阴性乳腺癌 (TNBC) 的关键驱动因素. 它们的相互作用促进瘤生长,减少存活率,提供潜在的治疗点.

关键词:
细胞迁移 细胞迁移表皮 mesenchymal 过渡的转变.纤维细胞生长因子受体1葡萄糖蛋白非转移性黑色素瘤蛋白B三重阴性乳腺癌是什么?

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