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受体放射性核酸治疗是否仍然是治疗甲状腺髓性癌的有希望的选择?

Fernanda Accioly de Andrade¹, Daniel Bulzico^1,2, Rossana Corbo^1,2

¹Endocrine Oncology Unit, Brazilian National Cancer Institute, INCA, Rio de Janeiro, Brazil.

|November 28, 2024

概括

脊髓甲状腺癌 (MTC) 治疗进展,用于RET突变癌症的RET抑制剂. 受体放射性核素疗法 (PRRT) 正在探索RET阴性MTC,在其他选择失败时提供一种潜在的替代方案.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
核医学就是核医学.

背景情况:

骨髓性甲状腺癌 (MTC) 通常是由RET原瘤基因突变引起的.
选择性RET抑制剂对RET突变的MTC是有效的,但对RET阴性疾病是有限的.
目前对RET阴性MTC的治疗方法存在耐药性问题和显著的副作用.

研究的目的:

审查MTC中受体放射性核素治疗 (PRRT) 的证据.
在新兴的RET抑制剂疗法背景下讨论PRRT的局限性.

主要方法:

对MTC的PRRT研究的文献综述.
对PRRT疗效和安全数据的分析.
将PRRT与现有的MTC治疗方法进行比较.

主要成果:

在RET突变MTC中,RET抑制剂显示有效性和低毒性.
对于复发性或转移性RET阴性MTC存在很少有效的全身疗法.
PRRT显示出潜力,但需要对MTC进行进一步的临床研究.

结论:

RET抑制剂代表了对RET突变MTC的显著进展.
PRRT可能为RET阴性MTC提供治疗选择,但其作用需要进一步阐明.
在MTC中PRRT的临床实用性需要更多的证据,特别是考虑到向疗法的成功.

关键词:

在RET的基础上,RET是RET.骨髓和骨髓的部分转移性转移性转移性受体放射性核素疗法是一种受体疗法.甲状腺是什么?甲状腺是什么?

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