在跨越非洲族群的苏丹男性中对前列腺癌的流行病学研究
Dalia Ahmed1,2,3, Elsadig Ahmed Adam Mohammed4,5, Mohamed Elimam Mohamed Ahmed6,7
1Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan.
Scientific reports
|November 28, 2024
概括
苏丹男性的前列腺癌 (PCa) 诊断显示出种族差异. 虽然攻击性相似,但尼日尔 - 刚果群体的PSA较高,诊断年轻,非洲 - 亚洲群体显示出更多的围神经入侵.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 人口健康 人口健康
背景情况:
- 前列腺癌 (PCa) 在全球范围内是一个重大的健康问题.
- 了解PCa在不同人群中的人口和临床变化对于有针对性的干预至关重要.
- 关于非洲不同民族语言群体中PCa特征的数据有限.
研究的目的:
- 研究苏丹男性前列腺癌的人口统计和临床特征.
- 确定苏丹三大民族语言群体中PCa诊断和攻击性的潜在差异.
- 为开发与非洲相关的PCa风险模型做出贡献.
主要方法:
- 这是一项涉及532名苏丹男性的横截面研究,他们通过活检确认了前列腺癌.
- 从苏丹六个医疗中心收集的数据.
- 对人口统计数据,临床阶段,年级组,前列腺特异性抗原 (PSA) 水平和跨民族语言群体的围神经入侵进行分析.
主要成果:
- 大多数 (84.2%) 患者被诊断为晚期PCa (等级组>3).
- 在民族语言群体之间没有发现PCa攻击性的显著差异.
- 尼日尔 - 刚果组显示PSA水平较高 (>50 ng/ml在55.2%) 和在诊断时的年龄较小.
- 非洲裔亚洲人群在年龄相匹配的子组中表现出更高的围神经侵入率.
结论:
- 苏丹男性的前列腺癌诊断通常发生在晚期阶段.
- 不同的临床特征,包括PSA水平,诊断时的年龄和围神经侵入,与苏丹的特定民族语言群体有关.
- 需要对非洲遗传多样性人口进行进一步的研究,以完善PCa风险模型并解决健康差异.
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