在人类产前发育过程中,初级和二级视野形成的异质性
Olga Godovalova1, Alexandra Proshchina2, Anastasia Kharlamova2
1Avsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", Tsurupi Street, 3, Moscow, 117418, Russia. godovalova.brain@gmail.com.
Biological research
|November 28, 2024
概括
人类大脑发育显示视觉场17,与状结相关,在视觉场18和19之前形成. 叶的这种结构变化与功能专业化相吻合.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 人类解剖学 人类解剖学
背景情况:
- 人类新皮质的庞大表面积,主要在内,表现出独特的细胞架构学.
- 宏观地标,比如状,与特定的细胞架构学领域有关,特别是主要视野17.
- 在初始形成后,新皮层和在产前发育过程中经历了显著的修改.
研究的目的:
- 研究在人类胎儿大脑中初级和二级的形成过程中视觉场中的形态遗传过程.
- 为了比较质和神经元标记物的分布,在calcarine和 parietooccipital sulci.
- 阐明早期视觉皮层发育中的结构变化和功能差异化之间的发展关系.
主要方法:
- 在人类胎儿大脑中,对尾叶的免疫组织化学分析.
- 对质 (S-100) 和神经元标记物 (β-III-tubulin,NeuN,reelin) 分布的比较研究.
- 检查形形成和细胞架构学场的发展.
主要成果:
- 在初级和二级视觉场的形成中表现出异质性.
- 揭示了第17个主要视野 (calcarine sulcus) 的发展先于第18个和第19个视野 (parietooccipital sulcus) 的发展.
- 观察到,初级视野的功能差异化与乳头 afferent 内生长和 calcarine sulcus 平滑相关,表明同时结构和功能进展.
结论:
- 初级视觉皮层 (第17个字段) 的发育在结构和功能上与皮形成有关.
- 突发育和相关视野成熟的时间是异质的,主要的视野发育较早.
- 晚期胎儿发育显示在皮质板银行与层深处的不同神经元标记表达 (NeuN),表明正在进行的成熟过程.
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