在多个血清性输液和严重的无性贫血病例中的毒素菌病
Xiaoning Wang1, Hao Li2, Le Ma1
1Department of Hematology, the First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, Shaanxi, P. R. China.
BMC infectious diseases
|November 28, 2024
概括
干细胞移植患者的毒素菌感染可能是致命的. 甲基因组测序迅速确定了Toxoplasma gondii在一个患有严重无形性贫血和多次出血的患者中,使得迅速诊断成为可能.
科学领域:
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
- 移植医学 移植医学
背景情况:
- 由Toxoplasma gondii引起的毒素,对免疫受损的个体构成严重的风险,可能导致多器官衰竭.
- 由于非特异性症状和需要显微镜确认tachyzoites,诊断往往会延迟.
研究的目的:
- 在干细胞移植接受者中报告Toxoplasma gondii感染病例.
- 突出元基因组下一代测序在快速诊断中的实用性.
主要方法:
- 一位患有严重的无形性贫血的患者在干细胞移植后出现了发烧和输液.
- 计算机断层扫描和超声波显示了多个血清性输液.
- 在血液和气泡泡洗液上进行了下一代元基因组测序.
- 对骨髓吸附物的显微镜检查证实了Toxoplasma gondii的tachyzoites和伪囊.
主要成果:
- 甲基因组测序检测出血液 (1.34%) 和气泡泡洗液 (17.09%) 中显著的Toxoplasma gondii序列.
- 显微镜分析证实了脊髓吸附物中含有塔基佐酸和伪囊的存在.
结论:
- 这一案例强调了在干细胞移植患者出现发烧和多次出血时考虑Toxoplasma gondii感染的重要性.
- 在如此复杂的情况下,元基因组测序为快速和准确的诊断提供了宝贵的工具.
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