在巴西探索饮食模式和胃腺癌之间的联系:调解分析
Alex Richard Costa Silva1, Gianfranco Alicandro2,3, Valdete Regina Guandalini4,5
1Graduate Program of A.C.Camargo Cancer Center, São Paulo, Brazil.
BMC medicine
|November 28, 2024
概括
调查饮食模式 (DPs) 和胃腺癌 (GA),这项研究发现不健康的DPs增加了GA风险,部分由添加糖介导. 健康的DP降低了风险,而摄入量起到了关键的调解作用.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 癌症研究 癌症研究
背景情况:
- 饮食模式 (DPs) 和胃腺癌 (GA) 之间的联系需要进一步阐明.
- 了解DP-GA关系中的营养调解对于有针对性的干预至关重要.
研究的目的:
- 在巴西人口中识别不同的饮食模式 (DPs).
- 评估特定营养素 (和脂肪酸,添加糖,总纤维,) 在DP和GA风险之间的关联中发挥的调解作用.
主要方法:
- 一个多中心病例控制研究,涉及1751名参与者 (600个GA病例,1151个对照).
- 探索性因子分析被用于识别DP.
- 基于反事实的调解分析量化了DPs通过营养摄入对GA的直接和间接影响.
主要成果:
- 确定了两个DP:"不健康的饮食模式" (UDP) 与增加的GA风险相关",健康的饮食模式" (HDP) 与风险降低相关.
- 添加糖部分调解了UDP-GA关联 (7.321.7%).
- 摄入量显著调解了HDP-GA关联 (52.4100%). 和脂肪酸和总纤维没有显著的调解.
结论:
- 饮食模式显著影响胃腺癌风险.
- 和添加糖是饮食模式和GA之间的关系中的关键调解营养素.
- 研究结果为制定GA的预防策略和公共卫生干预措施提供了宝贵的见解.
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