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Updated: Jun 6, 2025

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Pin1通过RNF138促进人体CaV2.1通道聚基化:对2型情节性性动脉的病理生理学影响

Ssu-Ju Fu1, Kai-Min Cheng1, Cheng-Tsung Hsiao1,2,3

  • 1Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.

Cell communication and signaling : CCS
|November 28, 2024
PubMed
概括

基基 cis/trans 异构酶,NIMA 相互作用的 1 (Pin1) 调节了 ER 中的 CaV2.1 通道蛋白质稳定. Pin1促进了CaV2.1的降解,其抑制改善了CaV2.1的水平和功能.

关键词:
道病变是一种通道病变.E3 无处不在的合酶质量控制ER质量控制ER质量控制乙基-乙基 cis/trans 异构酶蛋白质体中的降解.蛋白质稳定性 蛋白质稳定性

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