与没有下肢并发症的糖尿病患者相比,糖尿病患者的下肢并发症认知变化:系统性审查和元分析
Nimantha Karunathilaka1,2,3, Christina Parker4,5, Peter A Lazzarini4,6,7
1Center for Healthcare Transformation, Queensland University of Technology, Brisbane, QLD, Australia. nimantha.durage@hdr.qut.edu.au.
BMC endocrine disorders
|November 28, 2024
概括
与糖尿病相关的下肢并发症 (DRLECs) 可能会影响糖尿病患者的认知能力. 然而,目前的证据是不一致的,需要进一步高质量的研究来澄清DRLEC和认知功能之间的关联.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 与糖尿病相关的下肢并发症 (DRLECs) 越来越多地与糖尿病患者的认知变化有关.
- 现有研究提出了相互矛盾的发现,缺乏全面的系统审查.
- 本综述系统地评估了对具有或没有DRLEC的糖尿病患者认知功能的研究.
研究的目的:
- 系统审查和评估研究糖尿病相关的下肢并发症和糖尿病患者的认知功能之间的关系的研究.
- 综合当前关于糖尿病患者与没有DRLECs之间的认知差异的证据.
主要方法:
- 在七个主要数据库 (MEDLINE,PubMed,CINAHL,EMBASE,Cochrane,PsycINFO,Web of Science) 进行了系统的搜索,截至2022年8月22日.
- 两位独立作者对具有DRLEC和没有DRLEC的人的认知能力进行比较的研究进行了资格和方法质量的选.
- 符合资格进行元分析的研究需要比较的病例,控制和结果措施.
主要成果:
- 包括13项研究:其中11项研究的方法质量中等,一项研究的方法质量高,一项研究的方法质量低.
- 四项研究报告了显著的认知差异,四项发现了显著的关联,五项研究没有发现DRLEC和认知之间的差异或关联.
- 一个小的元分析表明,与没有 (MD = -0.49;95% CI: -1.590.61) 相比,患有外围神经病变的个体在认知方面没有统计学上显著的差异.
结论:
- 虽然与糖尿病相关的下肢并发症可能会影响糖尿病患者的认知能力,但证据仍然不确定.
- 研究方法的变化使得最终的结论变得复杂.
- 未来的高质量研究对于阐明DRLEC与糖尿病患者认知功能之间的确切关系至关重要.
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