在2型糖尿病中,晨间血清皮质醇水平和白天时间之间有较强的联系?
Yue Liang1, Jingjing Liang2, Wenwen Jiang3
1Department of Endocrinology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China.
在2型糖尿病患者中,较高的早晨皮质醇水平与降低范围时间 (TIR) 和增加葡萄糖变异性有关. 这表明不适当的皮质醇分泌会对血糖控制产生负面影响.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 糖尿病研究 糖尿病研究
背景情况:
- 下垂体-垂体-上腺 (HPA) 轴在葡萄糖平衡和糖尿病中发挥作用.
- 研究了在2型糖尿病 (T2DM) 中早晨血清皮质醇和葡萄糖控制之间的联系.
研究的目的:
- 检查T2DM患者的早晨血清皮质醇水平和时间范围 (TIR) 之间的关联.
- 评估皮质醇和血糖变化 (GV) 之间的关系.
主要方法:
- 早上8点测量了310名T2DM患者的血清皮质醇.
- 使用连续三天的葡萄糖监测 (CGM) 来评估TIR和GV.
- 评估胰岛素敏感性和小岛功能,使用标准化食测试.
主要成果:
- 较高的血清皮质醇与较低的TIR和目标范围内的时间 (TITR) 相相关.
- 皮质醇与白天TIR的负相关性比夜间TIR更强.
- 皮质醇与胰腺功能指标有负相关性,与GV参数有正相关性.
结论:
- 晨间血清皮质醇与TIR负面相关,特别是白天的TIR,与GV积极相关.
- 不适当的皮质醇分泌可能会对T2DM患者的葡萄糖平衡产生不利影响.
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