药剂师领导的氨基糖化物管理的影响:一项为期10年的观察研究
Yasutaka Shinoda1, Kengo Ohashi2, Tomoko Matsuoka2
1Department of Pharmacy, Ogaki Municipal Hospital, Gifu, Japan. shonoda065039@gmail.com.
药剂师主导的干预显著改善了适当的氨基糖化物使用和降低了成本,突出了药剂师参与管理这些关键抗生素和最大限度地降低患者风险的重要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 氨基糖化物对于治疗多药性耐药性格拉姆阴性感染和内心炎至关重要.
- 毒性是与氨基糖化物相关的重大风险,需要仔细剂量和治疗药物监测.
- 对氨基糖化物进行常规治疗药物监测并未得到广泛实施.
研究的目的:
- 评估药剂师驱动的治疗药物监测干预措施对氨基糖化物使用模式的影响.
- 评估干预对临床结果的影响,包括毒性和疗效.
- 为了确定药剂师领导的氨基糖化物管理的成本效益.
主要方法:
- 一个回顾性队列研究,包括从2014年到2023年用氨基甘油治疗的263名患者.
- 2017年实施药剂师主导的治疗药物监测干预措施.
- 分析氨基糖化物使用趋势,剂量适当性,血度监测,脏结果以及干预前后的临床疗效.
主要成果:
- 在初始处方时,适当的氨基糖化物使用率从49%增加到82% (P < 0.01).
- 药剂师参与初始剂量设计从21%增加到60% (P < 0.01),血液度监测从53%增加到72% (P < 0.01).
- 尽管功能障碍的发病率相似 (11%对12%),但病例的年平均数量有所下降,并且节省了56%的成本.
结论:
- 药剂师主导的氨基糖化物管理显著提高了适当的药物使用,并降低了成本.
- 药剂师的参与对于优化氨基甘油治疗至关重要.
- 需要进一步的研究来完善管理氨基糖化物血度的指导方针.
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