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评估皮表皮生长因子受体 (EGFR) 表达在UROTHELIAL CARCINOMA中的表达:可能的预测作用

Shifa Basharat¹, Ayesha Sajjad¹, Faryal Javaid¹

¹Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC

|November 29, 2024

概括

强烈的表皮生长因子受体 (EGFR) 表达表明尿路细胞癌的预后较差,这表明它有可能用于膀癌患者的向治疗.

科学领域:

在瘤学瘤学.
病理学病理学病理学
分子生物学分子生物学

背景情况:

尿癌是膀癌的一种流行和激进的形式.
它约占所有膀癌诊断的90%.
高发病率和高死亡率强调了需要更好的预后标志物.

研究的目的:

评估表皮生长因子受体 (EGFR) 的表达水平.
为了确定EGFR表达在尿路癌的预后意义.
探索EGFR作为治疗点的潜力.

主要方法:

一项涉及98个尿路细胞癌标本的横截面研究.
组织病理学检查包括瘤分类和入侵的评估.
皮肤上生长因子受体 (EGFR) 表达量化.
数据分析使用SPSS版本23进行.

主要成果:

总共分析了98名患者,平均年龄为58.68岁 (68.4%的男性).
更高的瘤等级 (p<0.001) 和更深的瘤入侵与强烈的EGFR表达相关.
在67.6%的高度瘤中观察到强烈的EGFR表达,而在低度瘤中观察到11.5%.

结论:

强烈的EGFR表达是尿路癌的显著预后指标.
在高度瘤中EGFR的作用表明其在指导向治疗中的有用性.
基于EGFR表达的向治疗可能会改善患者的治疗结果.

关键词:

泌尿器癌;EGFR;膀癌;膀癌.

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