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Updated: Apr 20, 2026

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利博西克利布诱导的自身免疫性类似肝炎:一个病例报告
Gozde Kavgaci1, Taha Koray Sahin1, Cenk Sokmensuer2
1Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkiye.
Journal of chemotherapy (Florence, Italy)
|November 29, 2024
概括
接受 ribociclib 治疗的激素受体阳性乳腺癌患者可能会患上药物诱导的自身免疫性类似肝炎. 仔细监测和管理对于平衡治疗疗效和肝脏安全至关重要.
科学领域:
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 激素受体 (HR) 阳性,人体表皮生长因子受体2 (HER2) 阴性乳腺癌是最常见的亚型.
- 循环素依赖性激酶4/6 (CDK4/6) 抑制剂加上内分泌疗法 (ET) 提高了生存率,但可能导致肝功能障碍.
- 作为CDK4/6抑制剂的利博西基布与肝酶升高和严重的肝功能障碍有关.
研究的目的:
- 报告一种药物诱导的自身免疫性类似肝炎 (DI-ALH) 病例,该病例发生在接受ribociclib治疗的转移性乳腺癌患者身上.
- 突出多学科管理在治疗CDK4/6抑制剂治疗期间治疗肝毒性的重要性.
主要方法:
- 一名44岁妇女患有HR+/HER2转移性乳腺癌的病例报告.
- 患者接受了 ribociclib, letrozole 和 goserelin,发生了 3 级肝毒性.
- 通过肝活检证实了DI-ALH的诊断;治疗包括普雷迪尼索隆和阿扎西奥普林,随后重新引入里博西克利布.
主要成果:
- 患者患有3级肝毒性,诊断为DI-ALH.
- 通过免疫抑制疗法的成功管理允许重新引入利博西基利布和剂量升级.
- 该案例证明了管理 ribociclib 诱导的肝毒性的可行性.
结论:
- 药物诱导的自身免疫性肝炎是HR+/HER2-乳腺癌里博西基利布治疗的潜在并发症.
- 涉及瘤学家和肝病学家的多学科方法对于管理肝毒性至关重要.
- 将瘤学目标与肝病学安全之间的平衡对于患者的治疗结果至关重要.
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