单极性和双极性抑郁症中的残留性高睡眠症:一个系统性审查
Julia Kwaśna1, Aleksander Kwaśny1, Alina Wilkowska1
1Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
概括
残留性高睡眠症在抑郁症中很常见,影响日常生活. 虽然modafinil和CPAP在短期内表现有希望,但这种睡眠障碍的长期抑郁症治疗需要更多的研究.
科学领域:
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 从抑郁症中完全康复是目标,但许多患者仍然存在诸如高睡眠症等残留症状.
- 残留性高睡眠症是患有抑郁症的个体中普遍存在的,经常使人衰弱的症状.
- 对于抑郁症残留高睡眠症的程度,频率和有效治疗方法的了解有限.
研究的目的:
- 系统地审查和巩固当前关于抑郁症残留高睡眠症的流行情况的知识.
- 检查抑郁症患者残留高睡眠症的现有治疗选择.
- 识别研究中的差距和管理这种疾病的挑战.
主要方法:
- 从PubMed,科学网和Scopus系统审查文献.
- 在PROSPERO注册的协议 (CRD42023392062).
- 对研究的分析,重点是患病率和药物/非药物干预措施.
主要成果:
- 残留性高睡眠症在抑郁症中非常普遍.
- 莫达菲尼尔在随机对照试验中显示出短期有效性.
- 持续的正气道压力 (CPAP) 在患有并发性阻塞性睡眠呼吸暂停 (OSA) 的患者中显示出对过度嗜睡有希望.
- 含糊不清的定义和各种各样的评估尺度使研究和治疗评估复杂化.
结论:
- 在抑郁症中治疗残留高睡眠症是一个重大的临床挑战,因为其高患病率和有限的长期治疗疗效.
- 摩达菲尼尔增强剂和CPAP治疗显示出潜在的益处,但需要进一步研究.
- 更多的安慰剂受控随机试验对于标准化管理和评估治疗有效性至关重要.
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