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用Celugel生产的制药基质的风湿学性质

Monika Gasztych¹, Natalia Jurczak¹

¹Department of Physical Chemistry and Biophysics, Faculty of Pharmacy, Wroclaw Medical University, Poland.

Polimery w medycynie

|November 29, 2024

概括

根据成分,Celugel水凝配方表现出不同的透压力和粘度. 基乙烯纤维素度显著影响这些特性,表明适合于鼻腔药物输送.

科学领域:

制药科学制药科学
材料科学材料科学材料科学

背景情况:

水凝为制药配方提供生物相容性和良好的粘合性.
基于基乙纤维素 (HEC) 的水凝Celugel是波兰唯一批准的制药化合物基质.

研究的目的:

评估原材料成分对基于塞卢格尔的水凝透压和质性质的影响.
评估Celugel适用于特定制药应用的适用性.

主要方法:

准备了10种Celugel配方,含水量各不相同,添加了5%的糖糖.
测量了奥斯莫斯压力,动态粘度,pH值和表面张力.

主要成果:

配方成分显著改变了透压,大多数水凝是高透的 (1601,480 mOsm/kg H2O).
粘度随着Celugel度的增加而增加,范围从2.19到562.87mPa·s.

结论:

塞卢格尔的风湿性质和透压是依赖于度的.
塞卢格尔是用于鼻腔注射的药物配方的可行选择.

关键词:

这种药物是 Celugel.这是一种水凝.基乙基纤维素酸.这种压力是透压力.

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