非常长链PUFA-3对骨矿物化的影响
Martina Torrissen1,2,3, Elisabeth Ytteborg1, Harald Svensen2
1Nofima (Norwegian Institute of Food, Fisheries and Aquaculture Research), Ås1432, Norway.
The British journal of nutrition
|November 29, 2024
概括
饮食omega-3非常长链多不和脂肪酸 (n-3 VLC-PUFA) 增强了大西洋鱼的骨和皮肤矿化. 这些发现表明n-3 VLC-PUFA也可能影响人类的骨矿化过程.
科学领域:
- 水产养殖营养水产养殖营养
- 海洋生物学 海洋生物学
- 生物化学 生物化学
背景情况:
- 欧米茄-3 非常长链多不和脂肪酸 (n-3 VLC-PUFA) 是具有已知的健康益处的必需营养素.
- 它们在骨健康中的作用,特别是在养殖鱼和潜在的人类应用中,需要进一步研究.
研究的目的:
- 为了确定饮食中的n-3VLC-PUFA补充是否会在体内增强大西洋鱼 (Salmo salar) 的皮肤和骨矿化.
- 探索n-3 VLC-PUFA对人类骨质母细胞增殖,分化和基因表达的体外影响.
主要方法:
- 大西洋鱼被养了不同饮食水平的n-3 VLC-PUFA.
- 分析包括组织脂肪酸组成,骨形态,矿物质含量,骨矿物质密度 (BMD) 和基因表达.
- 在体外研究中利用人类胎儿骨质母细胞来评估细胞的增殖,分化和细胞因子表达.
主要成果:
- 饮食中增加的n-3 VLC-PUFA水平导致了鱼的脊椎矿物质含量和骨质量增加.
- 在鱼中观察到骨相关基因表达的微妙但显著的变化.
- 在体外实验表明n-3 VLC-PUFA对骨质生标记物和细胞因子基因表达的潜在影响.
结论:
- 饮食n-3 VLC-PUFA对大西洋鱼的骨和皮肤矿化有积极的影响.
- n-3 VLC-PUFA可能在调节骨矿化过程中发挥作用,这可能对人类健康产生潜在影响.
更多相关视频
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
9.3K
07:53Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
Published on: December 10, 2010
18.0K
相关概念视频
01:31Essential Minerals for Bone Health
3.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.8K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:40Bone Remodeling
38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K