CK5/6 侵入性管道癌分子亚型中的表达
Rafeya Yasin1, Ghazi Zafar1, Fatima Rooman Ali Syed1
1Histopathology, Chughtai Institute of Pathology, Lahore, PAK.
Cureus
|November 29, 2024
概括
侵袭性导管癌 (IDC) 中的细胞克拉丁5/6 (CK5/6) 表达与侵袭性乳腺癌亚型有关. CK5/6阳性与三阴性乳腺癌和不良预后指标有关.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 生物标志物研究 生物标志物研究
背景情况:
- 乳腺癌 (BC) 是全球癌症相关死亡的主要原因,巴基斯坦的发病率正在上升.
- 侵入性导管癌 (IDC) 是BC最常见的组织学亚型.
- 分子亚型 (Luminal A,Luminal B,HER-2丰富,三阴性) 影响预后,三阴性BC具有最糟糕的前景.
研究的目的:
- 为了评估IDC中的细胞克拉丁5/6 (CK5/6) 的表达.
- 为了比较BC的不同分子亚型中的CK5/6表达.
- 在IDC中将CK5/6表达与已确定的预后因素相关联.
主要方法:
- 一项涉及85个乳腺切除样本的横截面研究,诊断出IDC.
- 对雌激素受体,孕激素受体,HER-2和CK5/6.6的免疫组织化学评估.
- 根据受体状态将病例分为分子亚型.
- 使用SPSS版本25.0.0进行统计分析.
主要成果:
- 在85例IDC病例中,有19例 (22.3%) 观察到CK5/6阳性.
- 大多数CK5/6-阳性病例 (68%) 是三阴性乳腺癌.
- 没有 Luminal A 病例表达了 CK5/6,而 Luminal B (10.8%) 和 HER-2 丰富 (33.3%) 亚型显示了一些积极性.
- CK5/6阳性与淋巴血管侵袭 (42%) 和高组织学等级 (57.8%) 相相关.
结论:
- 在IDC中CK5/6表达与三重负分子亚型有显著的关联.
- CK5/6阳性表明与不良预后因素的相关性,包括高瘤等级,淋巴血管入侵,阳性结节状况和晚期病理阶段.
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