治疗急性白血病和骨髓质疏松症候群的最新进展和挑战:系统性审查

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Nawal Rafiq¹, Muhammad H Khan², Mashaal Sahibzada³

¹Accident and Emergency, Rehman Medical Institute, Peshawar, PAK.

Cureus

|November 29, 2024

概括

近期急性白血病 (AL) 和骨髓质疏松综合征 (MDS) 治疗的进展为患者提供了更好的治疗结果,特别是在老年人中. 诸如高成本和获取等挑战仍然存在,但新疗法承诺改善生活质量.

科学领域:

血液学血液学血液学
在瘤学瘤学.
翻译医学是一种翻译医学.

背景情况:

急性白血病 (AL) 和骨髓质疏松综合征 (MDS) 是具有显著死亡率的关键诊断,需要改进全球管理策略.
疾病的进展和外骨干干涉使治疗复杂化,强调了治疗进步的必要性.

研究的目的:

系统地审查最近在治疗AL (AML,ALL) 和MDS方面的进展和挑战.
评估治疗进展及其对患者结果的影响,特别是在老年人中.

主要方法:

在遵守PRISMA指南的基础上进行系统审查.
在主要数据库 (PubMed,Scopus等) 中进行文献搜索. 对于发表在2017-2024年期间的文章.
根据定义的纳入/排除标准,选择了12项同行评审的研究.

主要成果:

诊断,分类和治疗方面的进步带来了改善的结果,包括长期存活和完全缓解.
针对性药物,免疫疗法和双特异性T细胞参与剂等较少毒性疗法对老年ALL患者显示出有前途.
了解AML遗传学的进展使得个性化疗法成为可能;MDS治疗结合化疗,向疗法和干细胞移植以获得高疗效.

结论:

最近的治疗进展为AL和MDS患者改善生活质量提供了希望.
挑战包括高昂的治疗费用,有限的获取和不充分的认识,需要进一步关注.
个性化和少有毒的治疗方法是有效管理AL和MDS的关键,特别是在脆弱人群中.

关键词:

患有急性白血病的人.挑战挑战挑战挑战挑战发展发展发展经济影响经济影响骨髓分裂性综合征是什么?人们的生活质量.幸存率幸存率幸存率治疗治疗治疗治疗治疗治疗

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