在检测小肠病理方面,FIT是否有作用:一项前性研究
Priya Oka1,2, Calvin M Johnson1,2, Mark McAlindon1,2
1Academic Unit of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, UK.
便免疫化学测试 (FIT) 并没有改善铁缺乏性贫血 (IDA) 患者小肠病理的检测. 虽然超过三分之一的患者有显著的发现,但FIT没有提供额外的诊断益处.
科学领域:
- 胃肠病学 胃肠病学
- 诊断医学 诊断医学 诊断医学
- 临床研究 临床研究
背景情况:
- 便免疫化学测试 (FIT) 检测出便中的人类血液.
- 它在查小肠病理方面的实用性尚未得到充分证实.
研究的目的:
- 评估FIT在诊断出缺铁性贫血 (IDA) 的患者中预测小肠病理方面的作用.
主要方法:
- 一项涉及成年人 (18-80岁) 的前性研究,IDA被指向内镜检查.
- 患者接受了FIT测试和小肠囊内镜 (SBCE).
- 一个由100名没有FIT测试的IDA患者组成的对照组也患有SBCE.
主要成果:
- 在FIT组的79名患者中,有44%的患者在SBCE上显示出显著的小肠发现,最常见的是血管切除.
- 一个积极的FIT结果 (>10) 显示出低灵敏度 (34.29%) 和特异性 (54.55%).
- 年龄是SBCE积极结果的唯一预测因素 (OR 1.06).
结论:
- 显著的小肠病理在IDA患者中很常见.
- 在这个患者队列中,FIT测试没有为检测小肠病理提供额外的诊断价值.
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