对被诊断患有CASK基因相关残疾的儿童进行ACQUIRE疗法的临床使用
Dory A Wallace1, Mary Rebekah Trucks1, Stephanie C DeLuca1
1Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA.
Advances in rehabilitation science and practice
|November 29, 2024
概括
在所有具有CASK突变的儿童中,ACQUIRE疗法改善了接受性沟通. 观察到运动技能的提高,特别是在干部控制,粗达和精细运动能力方面,突出显示了治疗的有效性.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 儿科康复儿童康复中心
背景情况:
- CASK基因突变与全球发育迟缓 (GDD) 有关.
- 强化治疗干预对于患有神经发育障碍的儿童的授权/康复至关重要.
- ACQUIRE治疗是一种基于学习原则的密集方法.
研究的目的:
- 评估ACQUIRE疗法对患有CASK突变的儿童的实践证据.
- 记录该群体的临床发现和密集康复的结果.
主要方法:
- 一个由20名具有CASK突变的女性 (12-128个月) 组成的临床队列参与了研究.
- 高剂量的ACQUIRE疗法由职业治疗师在4周内 (平均64小时) 进行.
- 干预针对执行控制和实践,使用日常治疗文档的数据.
主要成果:
- 所有孩子都在接受性沟通方面表现出改善.
- 显著的运动技能改进包括干控制 (33%),粗达 (21%),和精细运动技能 (19%).
- 在所有参与者中都记录了认知运动技能配对.
结论:
- 在ACQUIRE治疗中,ACQUIRE疗法被证明是对患有CASK突变的儿童的有效干预措施.
- 定制的干预目标,如注意力和认知运动技能,对于这个群体来说至关重要.
- 这些发现支持使用特定于诊断的,强化治疗GDD的方法.
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