临床前查心血管疾病与高灵敏度心脏托罗波宁:准备好,设置,开始?
Aya Awwad1, Yashika Parashar1, Soahum Bagchi1
1Postgraduate Research Program, Harvard Medical School, Boston, MA, United States.
高灵敏度的素测定可以检测隐性心血管疾病 (CVD),并识别对未来事件的高风险个体. 测量心脏热素 (cTnT和cTnI) 可能使早期,积极的风险因素管理,以预防心肌梗塞和心血管死亡.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 预防医学 预防医学
背景情况:
- 心血管疾病 (CVD) 往往在多年内保持无症状,这构成了诊断挑战.
- 目前的预防性治疗可以减轻心肌梗塞 (MI) 和心力衰竭等风险.
- 心脏热素 (cTnT,cTnI) 是已确立的MI生物标志物,最近的高灵敏度 (hs) 测定提高了检测能力.
研究的目的:
- 审查支持hs-cTnT和hs-cTnI用于心血管风险查的证据.
- 探索高hs-cTn水平与隐性心血管疾病之间的关联.
- 为了说明hs-cTn查如何指导积极的风险因素管理.
主要方法:
- 关于心脏热素测定和心血管疾病的现有文献的综述.
- 对横截面成像研究的分析,这些研究将hs-cTn水平与心血管疾病相关联.
- 检查临床情景,证明hs-cTn查对患者结果的影响.
主要成果:
- 高灵敏度的素测定现在可以在50%以上的一般人群中测量cTnT和cTnI.
- 升高的hs-cTn水平显然与未来心血管事件的风险增加有关.
- hs-cTn水平与亚临床心血管疾病相关,包括冠状动脉疾病和心肌纤维化.
结论:
- 测量hs-cTnT和hs-cTnI是一个有前途的策略,用于查患心血管疾病风险的个体.
- 早期识别高水平的热波可以促进及时和积极的管理可修改的风险因素.
- 这种方法有可能通过预防主要心血管事件来改善患者的治疗结果.
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