升高的残留胆固醇和患有严重抑郁症的风险:全国性基于人口的研究
Shiyi Tao1,2, Lintong Yu2, Jun Li1
1Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in psychiatry
|November 29, 2024
概括
升高的残留胆固醇 (RC) 与美国成年人患重度抑郁症 (MDD) 的风险更高有关. 管理RC和相关条件可能有助于减少MDD的发生.
科学领域:
- 心血管健康和精神健康
- 代谢综合征和精神疾病
背景情况:
- 剩余胆固醇 (RC) 越来越多地被认为与各种疾病有关.
- 有限的基于人群的研究存在于RC和主要抑郁障碍 (MDD) 之间的关系.
- 这项研究调查了RC和MDD在美国成年人群中的关联.
研究的目的:
- 确定美国成年人残留胆固醇水平与主要抑郁症 (MDD) 之间的关联.
- 用各种统计模型评估RC在识别MDD方面的表现.
主要方法:
- 利用来自2005-2018年国家健康和营养检查调查 (NHANES) 的横截面数据.
- 使用患者健康问卷 (PHQ-9) 评估MDD并分析RC水平.
- 采用多变量逻辑回归,线条平滑,ROC分析和决策曲线分析 (DCA).
主要成果:
- 较高的RC四分位数与更高的PHQ-9分数和增加的MDD患病率有关.
- 在完全调整的模型中,观察到RC和MDD (OR=1.43,95%CI 1.15-1.78) 之间的正相关性.
- 最高的RC四分位数显示MDD风险比最低的风险高32% (OR=1.32,95% CI 1.05-1.66).与此相比,最高的RC四分位数显示MDD风险高32%.
结论:
- 升高的RC与美国成年人中流行MDD的风险更高显著相关.
- 这种关联在糖尿病,高血压或高脂血症患者中尤为明显.
- 管理RC水平和并发症可能在缓解MDD发生方面发挥作用.
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