作为中风的标志物,加多泄漏到眼部结构中:对WAKE-UP试验的回顾性分析
Anke Wouters1, Tim Van Assche1, Lauranne Scheldeman2
1Department of Neuroscience, KU Leuven, Leuven, Belgium.
European stroke journal
|November 29, 2024
概括
加多流入眼部结构 (GLOS) 在急性缺血性中风中很常见,与老年和更差的功能有关,但不是出血变化或不良结果.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 眼科医生 眼科 眼科
背景情况:
- 血脑屏障的破坏在急性缺血性中风中很常见.
- 加多泄漏到脑脊液 (HARM) 中表明血脑屏障功能障碍.
- 血眼屏障功能障碍 (GLOS) 是一个潜在的并发症.
研究的目的:
- 在WAKE-UP试验中调查GLOS的流行情况.
- 确定GLOS与HARM,出血转化 (HT) 和功能结果的关联.
主要方法:
- 从WAKE-UP试验中随机选择的192/503 (38%) 患者的分析.
- 使用流体减弱反转恢复 (FLAIR) 成像对GLOS的评估.
- 对GLOS与基线和结果变量相关性的统计分析.
主要成果:
- 在29%的患者中检测到GLOS,比HARM频率高四倍 (7%).
- 阳性GLOS患者年龄较大,GFR较低,白质高强度体积较高.
- 在多变量分析中,GLOS与HT或功能性结果不佳无关.
结论:
- GLOS是急性缺血性中风的常见发现.
- GLOS与老年,更差的功能和增加白质超强度负担有关.
- GLOS与出血转变或功能结果无关.
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