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肝癌中CALCR表达的作用:对免疫疗法反应的影响

Sijia Wang¹, Wei Wang², Jia Zeng¹

¹Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410001, P.R. China.

Molecular medicine reports

|November 29, 2024

概括

素受体 (CALCR) 是肝肝细胞癌 (LIHC) 的显著预后标志物. 高CALCR表达与更短的存活期有关,而其抑制减少了癌细胞迁移和扩散.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症基因组学癌症基因组学

背景情况:

肝肝细胞癌 (LIHC) 是癌症死亡的主要原因.
纤维化和铁化是LIHC发展中的关键过程.
在LIHC中,素受体 (CALCR) 的预后和功能作用尚不清楚.

研究的目的:

研究LIHC中CALCR的表达和预后意义.
探索CALCR与LIHC中的纤维化,铁化和免疫透的关联.
确定CALCR在LIHC细胞行为中的功能作用.

主要方法:

利用癌症基因组图谱 (TCGA) 和分子签名数据库用于基因表达和患者数据.
基于纤维化基因的LIHC患者聚类的员工共识ClusterPlus.
进行了单样样本基因组丰富分析 (ssGSEA) 检测纤维化和铁化.
进行了相关性,存活率,名谱和胰腺癌分析.
通过细胞迁移,增殖和细胞亡试验在体外研究CALCR功能.

主要成果:

在LIHC患者中,CALCR表达与整体存活率 (OS) 和疾病特异性存活率 (DSS) 有显著的关联 (HRs>1.7).
高CALCR表达与较差的生存结果相关.
在LIHC细胞中,CALCR的淘汰减少了迁移和增殖,同时增加了亡.
CALCR表达模式影响了瘤免疫微环境,并建议差异化免疫疗法反应.

结论:

CALCR是LIHC的显著预后生物标志物,影响生存和基因组特征.
在LIHC细胞迁移,增殖和亡中,CALCR起着重要作用.
在LIHC中,CALCR可以作为潜在的治疗标和免疫疗法疗效的预测指标.

关键词:

卡尔西托尼尼受体的受体是什么铁性化 (ferroptosis) 是一种纤维化纤维化基因组异质性的基因组异质性肝脏肝细胞癌是肝脏细胞癌.

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