DISCOVER CKD前性队列的基线特征
Carol Pollock1, Juan-Jesus Carrero2, Eiichiro Kanda3
1Kolling Institute, Royal North Shore Hospital, University of Sydney, 10 Westbourne St, St Leonards, Sydney, NSW, 2064, Australia. carol.pollock@sydney.edu.au.
Advances in therapy
|November 29, 2024
概括
现实数据显示,慢性病 (CKD) 患者面临显著的症状负担,影响生活质量. 尽管有当代护理,但治疗方面的差距仍然存在,这凸显了CKD管理中的未满足需求.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 流行病学 流行病学
- 现实世界的证据.
背景情况:
- 对于慢性病 (CKD) 患者,现实世界数据有限,特别是在临床管理,治疗模式和与健康相关的生活质量 (HRQoL) 方面.
- 了解这些方面在不断发展的疗法和更新的护理标准指南的背景下至关重要.
研究的目的:
- 描述DISCOVER CKD研究的前阶段的成年人的人口统计数据,基线特征和患者报告的结果.
- 评估现实世界的临床管理,治疗模式和HRQoL在多样化的CKD患者群体中.
主要方法:
- 观察性队列研究 (DISCOVER CKD) 招募了患有CKD的成年患者.
- 根据ICD-10代码定义的CKD或两个估计的淋巴膜过率 (eGFR) 测量<75毫升/分钟/1.73米2,隔91-730天记录.
- 收集关于人口统计,基线特征和患者报告结果的数据.
主要成果:
- 从6个国家招募了1052名患者,69.1%患有2-3b阶段的CKD,30.9%患有4-5阶段的CKD.
- 相关疾病的高患病率:高血压 (72.4%),糖尿病 (43.0%),高脂血症 (37.5%).
- 与 stadium 4-5 CKD 患者相比,患有 stadium 2-3b CKD 的患者报告了更大的症状负担,更糟糕的HRQoL (SF-36) 和更大的工作损伤 (WPAI-CKD). 在晚期的CKD中观察到较高的贫血,高血和的发病率.
结论:
- 当代现实世界的数据突出显示,在多个国家的CKD患者中,症状,药物和心理社会负担是相当大的.
- 在CKD治疗和管理方面仍然存在重大差距,这表明患者的需求尚未得到满足.
- 这项研究为CKD患者的现实体验提供了宝贵的见解,为未来的研究和临床实践提供了信息.
相关概念视频
01:12Internal Anatomy of the Kidney
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The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
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01:17Factors Affecting Renal Clearance: Renal Impairment
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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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01:23Renal Clearance
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The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
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01:23Assessment of the Cardiovascular System I: Subjective Data
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A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
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Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
278
01:10Nephrons
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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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01:24Renal Tubule and Collecting Duct
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The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
807