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胰岛素需求和胰岛素充足度在一生中变化的关系
Yingchai Zhang1,2,3, Claudia H T Tam1,2,3, Eric S H Lau1,2,3
1Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
青少年表现出不平衡的胰岛素需求和充分性,增加异常葡萄糖耐受性风险. 一个新的RAD指数有效地识别了跨生命阶段的这种不平衡.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 人体生理学 人体生理学
背景情况:
- 在人类成长和发育过程中,胰岛素需求会动态变化.
- 了解胰岛素需求和足够性之间的相互作用对于代谢健康至关重要.
- 以前的研究还没有完全阐明胰岛素动态的生命周期变化.
研究的目的:
- 评估胰岛素需求和胰岛素充足度之间的终身关系.
- 引入和验证一个新的指数 (RAD) 来评估这种关系.
- 确定胰岛素平衡与异常葡萄糖耐受性 (AGT) 风险之间的关联.
主要方法:
- 使用口服葡萄糖耐受性测试 (OGTT) 对三个独立的中国队列 (儿童,青少年,成年人) 的分析.
- 从配对的葡萄糖/胰岛素值计算胰岛素敏感度和分泌指数.
- 从胰岛素充足度和需求得出RAD指数,并使用后勤回归和歧视分析评估AGT风险.
主要成果:
- 青少年的胰岛素敏感性最低,胰岛素分泌量最高,导致胰岛素需求最高,禁食胰岛素充足度最低.
- 青少年通常呈现负RAD值,表明胰岛素关系不平衡,与具有正RAD值的儿童和成年人不同.
- 较低的RAD指数值与所有OGTT阶段的AGT风险增加显著相关,晚期RAD指数显示出最好的预测性能.
结论:
- 胰岛素需求与足够性之间的关系在人类一生中显著变化.
- 与儿童和成年人相比,青少年在胰岛素需求和充足度方面经历了明显的不平衡.
- RAD指数是一种新且有效的工具,用于表征胰岛素平衡,并预测终身AGT风险.
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