相关实验视频

Updated: Jun 6, 2025

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

在GlycoPOST和UniCarb-DR的合作中,建立了一个全面的糖化学品数据库工作流程

Yushi Takahashi¹, Niclas G Karlsson², Shujiro Okuda¹

¹Medical AI Center, Niigata University School of Medicine, Niigata, Japan.

Analytical and bioanalytical chemistry

|November 29, 2024

概括

现在,Glycomics的研究人员可以使用集成的数据库GlycoPOST和UniCarb-DR. 这次升级统一了提交系统,增强了交叉引用,并改善了质谱实验的数据可视化.

科学领域:

葡萄糖化合物和葡萄糖蛋白质组合物
计算生物学计算生物学
生物技术是生物技术.

背景情况:

葡萄糖和葡萄糖蛋白质的质谱学实验产生了大量的数据.
现有的数据存储库,如GlycoPOST和UniCarb-DR存储这些有价值的信息.
这些存储库之间加强的相互关系对于数据的可访问性和分析至关重要.

研究的目的:

升级GlycoPOST和UniCarb-DR的框架,以实现更好的整合.
统一数据提交系统,并使存储库之间自动交叉引用成为可能.
改进元数据注册和数据可视化能力.

主要方法:

统一的数据提交系统用于GlycoPOST和UniCarb-DR.
在两个存储库之间实施了自动交叉引用机制.
扩展元数据注册,以包括液体染色学MIRAGE (糖化合物实验所需的最低信息) 标准.
增强可视化软件,允许查看禁运,未发表的实验数据.

主要成果:

成功地整合了GlycoPOST和UniCarb-DR框架.
增强数据提交和交叉引用能力.
用于液体染色学实验的标准化元数据报告.
新功能可用于可视化未发表的,禁运的糖性成分数据.

结论:

为GlycoPOST和UniCarb-DR建立了一个新的综合框架.
这一框架提高了糖性化学品研究人员的数据可访问性和可用性.
整合方便了更全面的方法来分析甘氨酸和甘氨酸蛋白质组的数据.

关键词:

数据仓库数据仓库.格莱科因信息学是一种信息学.格莱科米克斯 (Glycomics) 是一个有趣的药物.液体色谱学液体色谱学液体色谱学质谱测量质量谱测量这些元数据是元数据.

更多相关视频

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

相关概念视频

Protein Glycosylation

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...

Oligosaccharide Assembly

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...