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Updated: Jun 6, 2025

Investigating Intestinal Barrier Breakdown in Living Organoids
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由m6A修饰诱导的下调KLF4,在炎症性肠病中加剧肠道屏障功能障碍

Xingchao Zhu1,2,3, Jiayu Wang1,2,3, Huan Zhang1,3

  • 1Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, 215000, China.

Cellular and molecular life sciences : CMLS
|November 29, 2024
PubMed
概括

克鲁佩尔样因子4 (KLF4) 在炎症性肠病 (IBD) 中降低,恶化肠上皮屏障 (IEB) 损伤. 向KLF4显示出通过恢复IEB功能来治疗IBD的前景.

关键词:
圆结复合体是指一个圆结复合体.细胞灭亡 (apoptosis) 是一种死亡的过程.炎症性肠病是一种炎症性肠病.肠道上皮质屏障 肠道上皮质屏障在KLF4KLF4m6A 修改 的 修改.

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