以药用植物和传统知识为指导的策略来打击艾滋病毒的持续性
Khumoekae Richard1,2, Adi N R Poli1, Kerstin Andrae-Marobela3,4
1The Wistar Institute, Philadelphia, PA, USA.
Current HIV/AIDS reports
|November 29, 2024
概括
具有延迟逆转剂 (LRA) 特性的补充和替代药物 (CAM) 传统上用于艾滋病毒/艾滋病. 需要进一步的研究和与传统卫生从业人员的合作,以探索他们对艾滋病毒缓解的潜力.
科学领域:
- 传统医学是传统的医学.
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 联合抗逆转录病毒疗法 (cART) 对潜伏的HIV储存物无效.
- 目前没有一种延迟逆转剂 (LRA) 能够持续地减少人类的HIV储存量.
- 补充和替代药物 (CAM) 广泛用于艾滋病毒/艾滋病管理,其中一些具有LRA特性.
研究的目的:
- 审查CAM与LRA特性在艾滋病毒/艾滋病管理中的潜力.
- 探索传统卫生从业人员 (THPs) 在推动艾滋病毒治疗研究中的作用.
主要方法:
- 在艾滋病毒/艾滋病管理中使用CAM的文献综述.
- 在临床前模型中分析CAM与LRA属性的科学验证.
- 检查与THP合作模式.
主要成果:
- 来自Euphorbiaceae和Thymelaeaceae家族的植物含有激活蛋白酶C的LRAs.
- 具有LRA特性的CAM在HIV感染细胞和人性化小鼠中表现有前途.
- 与THP的合作可以培养信任,并提升对这些CAM的知识.
结论:
- 传统上用于艾滋病毒/艾滋病管理的CAM可能含有可行的LRA.
- 进一步的研究和与THP的合作对于利用CAM在艾滋病毒缓解和治愈工作中的潜力至关重要.
- 将传统知识与科学研究相结合,可以加速艾滋病毒治愈策略.
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