血清尿酸与中国正常人群糖尿病前期之间的关联:一个横截面研究
Keqing Shen1, Yilin Huang1, Junlu Zhang1
1Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Medicine
|November 29, 2024
概括
血清尿酸 (SUA) 的升高与更高的糖尿病前期患病率有关,特别是在男性中. 相反,高水平的SUA与患糖尿病的风险较低有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 心血管疾病的危险因素 心血管疾病的危险因素
背景情况:
- 糖尿病前期是心血管事件的重要危险因素.
- 血清尿酸 (SUA) 的升高越来越被认为是代谢功能障碍的潜在贡献者.
- 需要进一步阐明SUA水平与糖尿病前期之间确切的关系,包括潜在的性别差异.
研究的目的:
- 调查血清尿酸 (SUA) 水平与糖尿病前期的患病率之间的关联.
- 检查SUA和糖尿病前期之间的关联中潜在的性别差异.
- 探索SUA水平与糖尿病前期和糖尿病患病率之间的关系.
主要方法:
- 一项涉及190,891名健康检查参与者的横截面研究.
- 血清尿酸 (SUA) 水平以四分位数进行分析.
- 使用后勤回归和限制立方线 (RCS) 模型来评估关联和剂量反应效应,控制潜在的混因素.
主要成果:
- 较高的SUA水平 (Q4) 与糖尿病前期患病率的增加显著相关 (OR=1.378).
- 相反,较高的SUA水平 (Q4) 显示糖尿病风险降低 (OR=0.690).
- 在男性中,SUA和糖尿病前期之间的关联与女性相比更为明显 (相互作用的P<.001).
结论:
- 血清尿酸 (SUA) 水平升高与糖尿病前期的更高患病率密切相关.
- 在男性中,SUA和糖尿病前期之间的联系明显比在女性中强.
- 较高的SUA水平可能表明糖尿病前期风险增加,但矛盾的是,在这个人群中糖尿病风险降低.
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