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Updated: Jun 6, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

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和α-synuclein的液体-液体相分离:重叠神经病理的一个新途径

Leandro Cruz Rodríguez1, Nahuel N Foressi1, M Soledad Celej1

  • 1Departamento de Química Biológica Ranwel Caputto, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC, CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA, Córdoba, Argentina.

Biochemical and biophysical research communications
|November 29, 2024
PubMed
概括

液-液相分离 (LLPS) 驱动细胞凝结物的形成. 像Tau和α-synuclein这样的蛋白质的异常LLPS可能是神经退行性疾病重叠的基础,并提供治疗点.

关键词:
这就是阿尔茨海默病的原因.粉样蛋白是什么 粉样蛋白是什么凝结剂是一种凝结剂.神经退行发生神经退行.帕金森 帕金森症候群阶段分离 阶段分离 阶段分离

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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