双对应的欧米克朗BA.1疫苗增强剂增加了记忆B细胞宽度和对新出现的SARS-CoV-2变种的中和抗体
Lok Bahadur Shrestha1, Katie Tungatt2, Anupriya Aggarwal3
1The Kirby Institute, University of New South Wales, Sydney, NSW, Australia; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, NSW, Australia.
一种双价性COVID-19增强剂疫苗增强了中和抗体和B细胞对SARS-CoV-2变种的记忆反应,包括新型菌株. 这表明双价疫苗可以提供更广泛的保护,防止新出现的变种.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 预计双价疫苗将扩大对SARS-CoV-2变种的中和抗体反应.
- 关于抗体宽度与记忆B细胞 (MBC) 和T细胞反应之间的关系的数据有限.
- 这项研究研究了对单价抗和双价抗COVID-19增剂疫苗的免疫反应.
研究的目的:
- 为了比较单价和双价祖先/欧米克朗BA.1COVID-19增强疫苗引起的中和抗体,记忆B细胞和T细胞反应的范围.
- 评估疫苗类型对针对SARS-CoV-2变种组的免疫反应的影响.
主要方法:
- 测量了对多种SARS-CoV-2变异的中和活性.
- 量化受体结合域 (RBD) 特定的内存B细胞 (MBC) 和Spike特定的内存T细胞.
- 评估了在基线和补丁疫苗接种后一个月的免疫反应.
主要成果:
- 这两种疫苗都增加了对五种变异的中和抗体,双价疫苗对BA.1和JN.1的增加更大.
- 双相接种疫苗显著增加了BA.1特异性MBC反应和整体MBC宽度,这与中和抗体宽度相关.
- 这两种疫苗都提高了T细胞反应,但只有双价疫苗增强了对BA.1变种的反应.
结论:
- 双对应的COVID-19疫苗在产生广泛反应的B细胞方面具有优势.
- 增强的MBC反应表明,双价疫苗可能会对未来的SARS-CoV-2变种提供更好的保护.
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