林氏素作为一种促进生长的抗生素,诱导了动物的代谢和免疫失调
Hongyuhang Ni1, Haoze Wu2, Jing Wang3
1Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong; Department of Food Science and Nutrition, Faculty of Science, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
The Science of the total environment
|November 29, 2024
概括
动物生长促进剂,如林氏素显著增加生长率,但改变肠道微生物群,导致肝损伤和代谢功能障碍. 在释放到环境之前,全面的毒理学评估至关重要.
科学领域:
- 环境毒理学环境毒理学
- 动物生理学 动物生理学
- 微生物组研究的研究.
背景情况:
- 动物生长促进剂 (AGPs) 被广泛使用,引发了对环境释放和潜在的生态系统/野生动物健康风险的担忧.
- 了解AGP的毒理影响对于风险评估至关重要.
研究的目的:
- 为了研究林氏素,一个常见的AGP,对动物的代谢和生理功能的影响.
- 评估与AGP使用相关的潜在环境毒性和健康风险.
主要方法:
- 在小鼠模型中使用了多omics方法.
- 分析包括肠道微生物群组成,脂质概况,肝功能和炎症标志物.
主要成果:
- 林氏素暴露在8周内增加了小鼠生长率的50.11%.
- 观察到肠道微生物群的显著变化 (Firmicutes减少,大肠杆菌增加).
- 小鼠表现出改变的脂质特征,肝损伤 (早期的NAFLD),以及葡萄糖/胰岛素水平的破坏 (与T2DM相关).
- 林氏素抑制了炎症反应,可能增加感染易感性.
结论:
- 林氏素对动物健康产生有害影响,影响肠道微生物群,新陈代谢和免疫功能.
- 在释放到环境中之前,需要对林氏素和其他AGP进行全面的毒理评估.
相关概念视频
01:25Inducible Operons: lac Operon
9
The lac operon in Escherichia coli is a model for understanding inducible gene regulation and metabolic flexibility. It integrates local control by lactose and global regulation through catabolite repression, enabling E. coli to preferentially metabolize glucose when available and switch to lactose utilization when glucose is scarce.Structure and Function of the lac OperonThe lac operon contains three structural genes: lacZ (β-galactosidase), lacY (lactose permease), and lacA...
9
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
142
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
142
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K