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通过NIR激活的多功能药物用于癌症成像和治疗的联合应用
Paweł Repetowski1, Marta Warszyńska1, Janusz M Dąbrowski2
1Faculty of Chemistry, Jagiellonian University, 30-387 Kraków, Poland; Doctoral School of Exact and Natural Sciences, Jagiellonian University, 30-348 Kraków, Poland.
Advances in colloid and interface science
|November 29, 2024
概括
接近红外线 (NIR) 激活剂提供双重诊断和治疗癌症治疗. 本综述涵盖了它们的特性,纳米载体应用以及临床使用的挑战.
科学领域:
- 生物医学工程 生物医学工程
- 摄影化学的使用.
- 纳米技术纳米技术
背景情况:
- 结合诊断和治疗的多功能药物增强了癌症治疗的有效性.
- 近红外 (NIR) 激活剂由于低毒性和多功能性而具有前景.
- 这些药物在光动力学疗法 (PDT) 和光和光声成像的对比剂中是有效的.
研究的目的:
- 审查用于协同癌症检测,诊断和治疗的NIR激活剂.
- 探索NIR激活的氨酸,氨酸,氨酸和聚合诱导排放化合物的光物理和光化学特性.
- 讨论纳米载体的纳入,以提高剂的性能和有针对性的交付.
主要方法:
- 对NIR激活化合物的光物理和光化学性质的审查.
- 对纳米载体系统进行分析,以提高可溶性,稳定性和准性.
- 多模式成像 (光和光声学) 的应用概述.
主要成果:
- 在PDT,光成像和光声成像中,NIR激活剂显示出潜力.
- 纳米粒子配方可以改善药理动力学,药理动力学和瘤向.
- 多模式成像提供全面的诊断信息.
结论:
- 通过NIR激活的药物和纳米载体系统显示出增强癌症诊断和治疗的前景.
- 仍然存在挑战,包括光毒性,有限的组织透率和非目标效应.
- 未来的研究应该专注于下一代药物和平台,以改善临床实施.
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