和多醇基物质 (PFAS):人类生物监测和暴露模式的质谱分析趋势,来自最近的全球队列研究
Kyung Hwa Kee1, Jeong In Seo2, Su Min Kim2
1Pharmacomicrobiomics Research Center, College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea; Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Environment international
|November 29, 2024
概括
对于了解健康风险,对和多基物质 (PFAS) 的人类生物监测至关重要. 本综述强调了质谱学趋势,污染挑战和区域暴露模式,确定了关键的研究差距.
科学领域:
- 环境科学 环境科学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 和多醇基物质 (PFAS) 是普遍存在的环境污染物,人类暴露途径有记录.
- 人类接触PFAS引发了严重的健康问题,需要强有力的监测策略.
- 人类生物监测对于将PFAS暴露水平与不良健康结果相关联至关重要.
研究的目的:
- 审查目前基于质谱的分析技术,用于对PFAS的人类生物监测.
- 讨论样本准备,空格矩阵和背景污染方面的挑战.
- 分析区域PFAS暴露模式,重点关注美国和中国的队列研究.
主要方法:
- 对基于质谱的PFAS生物监测方法的当前趋势的审查.
- 探索分析策略,以克服样本准备和污染控制方面的挑战.
- 在过去五年中,美国和中国的国际队列研究的分析.
主要成果:
- 质谱技术广泛用于生物样本中PFAS评估.
- 在获得无PFAS空白矩阵和管理背景污染方面的挑战仍然存在.
- PFAS暴露模式的区域差异很明显,来自美国和中国的研究提供了具体的见解.
结论:
- 完善分析方法对于准确的PFAS生物监测至关重要.
- 解决污染和空格矩阵问题对于可靠的结果至关重要.
- 需要进一步的研究来填补PFAS在人类生物监测研究中发现的空白.
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