在内陆,沿海和岛屿种群的聚合血清中,每种和多基基物质度的空间变化
Julia J Orr1, Leisa-Maree Toms2, Peter Hobson3
1The University of Queensland, Queensland Alliance for Environmental Health Sciences, Woolloongabba, QLD, Australia.
Environmental research
|November 29, 2024
概括
与内陆居民相比,在澳大利亚岛屿和沿海人口中发现了某些per-和多基物质 (PFAS) 的较高血清水平. 这表明地理位置影响了这些持久化学物质的暴露.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 和多基基物质 (PFAS) 是广泛,持久和生物累积的化学物质.
- 饮食摄入,特别是海鲜消费,是PFAS的主要人类暴露途径.
- 靠近海岸可能会改变饮食习惯,并增加暴露于地理特定的PFAS来源,如海喷雾气溶.
研究的目的:
- 为了研究血清PFAS度的空间变化.
- 为了比较澳大利亚沿海和岛屿人口与内陆人口的PFAS水平.
- 评估使用聚合血清样本进行地理暴露趋势分析的可行性.
主要方法:
- 人类血清样本被取消识别,并根据地理位置,性别和年龄组进行聚合.
- 使用高性能液体色谱-质谱 (HP LC-MS) 分析了PFAS度.
- 在45种目标PFAS化合物中,13种化合物的量化得到了实现.
主要成果:
- 在45岁以上的男性中观察到显著的空间趋势.
- 岛屿地区的PFOS,PFBA,PFDA和PFHpS的血清度比内陆地区高32-77%.
- 在沿海地区也发现了PFHpS的类似趋势.
结论:
- 地理位置,特别是岛屿和沿海居民,与某些人口统计学群体的血清PFAS度较高有关.
- 这项研究表明,聚合样本对于评估人类暴露于PFAS的空间变化具有有用性.
- 需要进一步的研究来阐明导致这些观察到的趋势的特定暴露途径.
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