在没有主要心血管风险因素的成年人中,脂肪沉积和死亡率之间的关联
Sophie E Claudel1, Ashish Verma2
1Department of Medicine, Boston Medical Center, Boston, MA, USA.
Diabetes & metabolism
|November 29, 2024
概括
包括脂肪质量指数 (FMI) 在内的肥胖度指标预测了美国没有心血管疾病的成年人死亡风险. 特定的FMI类型和比率显示出与死亡率的明显关联,因性别而异.
科学领域:
- 内分泌学和新陈代谢学
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 肥胖与死亡率有关,但其在健康成年人中的预后价值需要进一步调查.
- 像BMI这样的传统人类计量可能无法完全捕捉与特定脂肪分布相关的死亡风险.
研究的目的:
- 为了研究各种脂肪测量和美国成年人没有主要心血管风险因素的全因死亡率之间的关联.
- 为了确定基于成像的脂肪度量是否提供超越标准测量的独特预后信息.
主要方法:
- 从NHANES (2003-2016) 对7948名美国成年人的分析,不包括患有心血管疾病,糖尿病或高血压的人.
- 使用双能X射线吸收计和人类计,包括各种脂肪质量指数 (FMI),BMI和腰围来评估脂肪度.
- 应用多变量调整的考克斯回归和受限制的立方脊柱模型来评估特定性别的死亡风险.
主要成果:
- 在7.8年的时间里,83名女性和119名男性死亡. 体重指数 (BMI),腰围和膝关节FMI显示了与女性死亡率的非线性关联.
- 在男性中,BMI,腰围和安卓与肌肉骨的比率表现出类似的非线性关联.
- 增加女性的内脏,皮下和腹部FMI,以及男性的骨头,骨,内脏,皮下和腹部FMI,与较高的死亡风险有显著的关联. 性别改变了形FMI和死亡率之间的关联.
结论:
- 从成像中获得的脂肪度量,如特定的脂肪质量指数,为死亡率提供了显著的预后价值.
- 这些详细的脂肪度指标提供了超越传统人体测量措施的增强风险预测在没有先前存在的心血管风险因素的成年人.
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