死亡风险的性别差异和与klotho水平的U形关系:长期队列研究
Junwen Wang1, Lin Bai1, Yuyang Ye1
1Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, China.
Experimental gerontology
|November 29, 2024
概括
克洛托水平对男性和女性的死亡风险的影响不同. 较高的克洛托与男性的死亡率增加有关,而女性则呈现出U形风险曲线.
科学领域:
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
- 生物统计学 生物统计学
背景情况:
- 克洛托,一种激素和死亡风险之间的关系需要进一步调查.
- 克洛托与死亡率相关的潜在基于性别的差异尚未得到充分证实.
研究的目的:
- 为了检查klotho水平和全因死亡率之间的关联.
- 专门调查这种关系中潜在的性别差异.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 在多变量分析中采用了Cox比例危险模型和Kaplan-Meier生存曲线.
- 评估了klotho水平对死亡率的影响,使用受限制的立方曲线.
主要成果:
- 包括13,748名参与者在分析中.
- 所有原因死亡的危险比率在男性中高于女性.
- 女性表现出一个U形的死亡风险曲线,klotho水平 (P=0.01非线性),达到959 pg/mL,而男性没有这种曲线.
结论:
- 克洛托水平和死亡风险表明性别特异性的U形关系.
- 与女性相比,高克洛托水平的男性面临更高的全因死亡风险.
- 这些发现强调了在与klotho相关的死亡率研究中考虑性别的重要性.
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