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异常的体重指数与多发性硬化症风险有关:系统性审查和元分析
Mohammad Mohammadi1, Aynaz Mohammadi1, Adrina Habibzadeh2
1School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Obesity research & clinical practice
|November 29, 2024
概括
肥胖显著增加患多发性硬化症 (MS) 的风险. 保持健康的体重可能会降低MS易感性,因为超重和肥胖的人面临更高的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肥胖与慢性低度炎症有关.
- 儿童和青少年肥胖与炎症标志物升高相关.
- 预炎症状态可能会影响多发性硬化症 (MS) 的发展.
研究的目的:
- 调查不同生命阶段的肥胖与MS风险之间的关联.
- 分析儿童,青少年和成年人体重状况对MS发展的影响.
主要方法:
- 发表文献的系统审查和元分析.
- 搜索了数据库,包括MEDLINE,Scopus,EMBASE和科学网络.
- 包括使用前发病体重指数 (BMI) 数据和健康对照的研究.
主要成果:
- 体重不足的人没有显著的MS风险 (RR 0.96).
- 超重的个体患MS风险增加了38% (RR 1.38).
- 肥胖个体面临88%的多发性硬化风险增加 (RR 1.88),比超重个体高得多的风险.
结论:
- 超重和肥胖与MS的风险增加有关.
- 体重管理对于MS易感性至关重要.
- 与肥胖相关的因素,如炎症,免疫反应和肠道微生物群,可能会导致MS风险.
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