在接受冠状动脉旁路手术的年轻患者中,家族性高胆固醇血症和心血管结果
Olivia G Deconinck1, James E Sharman2, Warrick Bishop3
1Royal Hobart Hospital, Hobart, Tas, Australia.
Heart, lung & circulation
|November 29, 2024
概括
家庭性高胆固醇血症 (FH) 在需要绕道手术的年轻患者中很常见. 早期FH检测和治疗对于更好的结果和手术后心血管事件减少至关重要.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 家族性高胆固醇血症 (FH) 是一种普遍的遗传疾病,导致高的LDL胆固醇和早期冠状动脉疾病.
- 人们对FH的认识不足,其患病率和年轻旁路手术患者的术后结果尚不清楚.
研究的目的:
- 为了确定FH在接受冠状动脉旁路手术的年轻患者的患病率.
- 评估手术前的LDL-C目标达到率和手术后的FH患者心血管事件发生率.
主要方法:
- 对60岁以下接受冠状动脉旁路手术的患者 (2008-2022) 的回顾性分析.
- 荷兰脂质临床网络得分用于诊断FH.
- 结果包括FH患病率,LDL-C目标的实现,以及主要的心血管不良事件.
主要成果:
- 13.6%的患者患有FH,42.2%可能患有FH.
- 与非FH患者相比,FH患者达到目标LDL-C (<1.8 mmol/L) 的可能性较低 (18.8%vs45.6%).
- 在FH患者中,术后心血管不良事件的发生率明显高 (aOR 2.52).
结论:
- 在接受冠状动脉旁路手术的年轻患者中,FH的流行率很高.
- FH患者在实现LDL-C目标方面面临挑战,并且在手术后心血管不良事件的风险增加.
- 在绕道手术前优先考虑FH检测和管理对于改善患者预后至关重要.
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