自复制分子之间的竞争排斥限制了化学多样化的趋势
Marcel J Eleveld1, Yannick Geiger1, Juntian Wu1
1Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Groningen, The Netherlands.
Nature chemistry
|November 29, 2024
概括
达尔文原则适用于化学,表明竞争性排斥限制了化学多样化. 自复制系统展示了资源分区如何允许多种化学物种的共存.
科学领域:
- 化学进化的化学演变.
- 生命的起源 生命的起源
- 系统化学 系统化学
背景情况:
- 从化学到生物学的过渡仍然不太了解.
- 关键问题涉及控制化学反应分歧和将达尔文原理应用于化学.
研究的目的:
- 调查竞争排除的进化原则是否适用于自我复制的化学系统.
- 为了确定达尔文原则是否可以限制化学多样化.
主要方法:
- 研究了两个自我复制的化学系统.
- 分析了不同资源条件下的准物种从构建块的出现和选择.
主要成果:
- 观察到三种不同的自我复制准物种从两个构建块中随机地出现.
- 证明,当资源均等使用时,竞争性排斥会选择单一的准物种.
- 证明了资源分区使多个准物种能够在进化稳定的状态下共存.
结论:
- 竞争性排斥的进化原则适用于自我复制的化学系统.
- 竞争性排斥限制了化学的多样化.
- 资源分割是化学进化系统中共存的一种机制.
相关概念视频
The Replisome
33.0K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
33.0K
Replication in Prokaryotes
24.3K
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
24.3K
Restriction Enzymes
29.5K
Restriction enzymes are bacterial enzymes used to cut DNA in a sequence-specific manner. To cleave DNA, they bind to specific palindromic sequences called restriction sites. Such palindromic DNA sequences or inverted repeats are commonly found in regions of functional significance, such as the origin of replication, gene operator sites, and regions containing transcription termination signals.
The host bacteria protect their own genomic DNA from these enzymes by methylating these sites. Some...
The host bacteria protect their own genomic DNA from these enzymes by methylating these sites. Some...
29.5K
DNA Replication
48.8K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied. After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
Replication in Prokaryotes
DNA replication...
48.8K
DNA Helicases
21.1K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
21.1K
Binary Fission
55.0K
Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in the Archaea and Bacteria domains reproduce using binary fission, in which a parent cell splits into two parts that can each grow to the size of the original parent cell. This asexual method of reproduction produces cells that are all genetically identical.
55.0K


